WDR72 · rs2459380
Where this position leads
Condition: Urolithiasis
What the study found
Who was studied 13,746 East Asian ancestry cases, 241,425 East Asian ancestry controls, 17,969 European ancestry cases, 702,230 European ancestry controls.
The effect Each copy of the A allele carried 0.94 times the odds of Kidney stone disease (95% confidence interval 0.92-0.95); p = 9 × 10−13.
How common The A allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 15, band 15q21.3 — in an intron of WDR72.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-12.
ClinVar record 1269936 NM_182758.4(WDR72):c.592-156A>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2459380 is a single position in the genome, in or near the WDR72 gene. Published research associates it with kidney stone disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Urolithiasis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:40216741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Kidney stone disease (rs2459380). MyGeneLog™. https://www.mygenelog.com/variants/rs2459380