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Weight

ONECUT1 · rs2456523

Where this position leads

Condition: Obesity and Body Weight

rs2456523 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs2456523 rs2456523 ONECUT1

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0085 lower (95% confidence interval 0.0061-0.0109); p = 4 × 10−12.

Where it sits Chromosome 15, band 15q21.3 — in the 5′ untranslated region of ONECUT1.

What each result means

G/G No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Weight. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures
Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P
Nature communications · 2025 · PMID 40436827 · open access

Questions about rs2456523

What is rs2456523?

rs2456523 is a single position in the genome, in or near the ONECUT1 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2456523 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs2456523 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2456523 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs2456523). MyGeneLog™. https://www.mygenelog.com/variants/rs2456523

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