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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 30,810 British ancestry individuals.
The effect
Each copy of the T allele shifted the measure 6.84 z score higher; p = 8 × 10−12.
How common The T allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 6, band 6q15 — between genes, 11.6 kb from U3.
What each result means
C/CNo copy of the version the research linked to Edge-level brain connectivity (multivariate analysis). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Edge-level brain connectivity (multivariate analysis). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Edge-level brain connectivity (multivariate analysis). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science advances · 2023 · PMID 36800424 · open access
Questions about rs2452946
What is rs2452946?
rs2452946 is a single position in the genome, in or near the near U3 gene. Published research associates it with edge-level brain connectivity (multivariate analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2452946 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2452946 come from?
GWAS Catalog, Science advances 2023, PMID:36800424. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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