0 1212225Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others5Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 53,711 European ancestry female cases, 380,441 European ancestry female controls.
The effect
Each copy of the A allele shifted the measure 0.0562 lower (95% confidence interval 0.041-0.071); p = 1 × 10−13.
Where it sits Chromosome 4, band 4q22.3 — in an intron of PDLIM5.
What each result means
A/ATwo copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40050615 · open access
Questions about rs2452597
What is rs2452597?
rs2452597 is a single position in the genome, in or near the PDLIM5 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2452597 linked to?
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
Does having rs2452597 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2452597 come from?
GWAS Catalog, Nature communications 2025, PMID:40050615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1212225Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others5Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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