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Who was studied 256,040 European ancestry individuals (MTAG effective sample size boosted by endometriosis, rheumatoid arthritis and multiple sclerosis samples).
The effect
Each copy of the C allele shifted the measure 0.014 lower (95% confidence interval 0.01-0.018); p = 8 × 10−11.
How common The C allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 2, band 2q33.2 — in an intron of RAPH1.
What each result means
C/CTwo copies of the version the research linked to Osteoarthritis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Osteoarthritis (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Osteoarthritis (MTAG). This is the starting point the study compared everyone against.
Human reproduction (Oxford, England) · 2025 · PMID 40262193 · open access
Questions about rs2443798
What is rs2443798?
rs2443798 is a single position in the genome, in or near the RAPH1 gene. Published research associates it with osteoarthritis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2443798 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs2443798 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2443798 come from?
GWAS Catalog, Human reproduction (Oxford, England) 2025, PMID:40262193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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