Sensitive

Chronic obstructive pulmonary disease

VGLL4 · rs2442776

Where this position leads

Condition: Chronic Obstructive Pulmonary Disease (COPD)

rs2442776 Condition: Chronic Obstructive Pulmonary Disease (COPD) Chronic Obstructive Pulmonary Disea… Condition rs2442776 rs2442776 VGLL4

What the study found

Who was studied 35,735 cases, 222,076 controls.

The effect Each copy of the G allele carried 1.09 times the odds of Chronic obstructive pulmonary disease (95% confidence interval 1.06-1.12); p = 2 × 10−10.

How common The G allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 3, band 3p25.3 — in an intron of VGLL4.

What each result means

A/A No copy of the version the research linked to Chronic obstructive pulmonary disease. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Chronic obstructive pulmonary disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Chronic obstructive pulmonary disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2442776

What is rs2442776?

rs2442776 is a single position in the genome, in or near the VGLL4 gene. Published research associates it with chronic obstructive pulmonary disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2442776 linked to?

On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.

Does having rs2442776 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2442776 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804561. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic obstructive pulmonary disease (rs2442776). MyGeneLog™. https://www.mygenelog.com/variants/rs2442776

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