2 472229123125Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 27,758 European ancestry individuals; replicated in 1,156 European ancestry cases, up to 42,617 European ancestry controls.
The effect
Each copy of the G allele carried 1.36 times the odds of Thyroid cancer (95% confidence interval 1.23-1.50); p = 2 × 10−9.
How common The G allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 8, band 8p12 — in an intron of NRG1.
How common each version is
CG
KoreanKRGDB
C 78.8% · G 21.2%
KoreanKorea4K
C 78.8% · G 21.2%
KoreanKorea1K
C 79.6% · G 20.4%
Japanese ToMMo
C 78.5% · G 21.4%
Vietnamese
C 79.9% · G 20.1%
World gnomAD
C 54.3% · G 45.7%
World 1000 Genomes
C 58.9% · G 41.1%
World TOPMed
C 54.6% · G 45.4%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
C/CNo copy of the version the research linked to Thyroid cancer. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Thyroid cancer. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Thyroid cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2439302 is a single position in the genome, in or near the NRG1 gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2439302 linked to?
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs2439302 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2439302 come from?
GWAS Catalog, Nat Genet 2012, PMID:22267200. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 472229123125Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs2439302). MyGeneLog™. https://www.mygenelog.com/variants/rs2439302