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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 47,079 British or unknown ancestry cases, 414,027 British or unknown ancestry controls; replicated in 98,298 cases, 247,446 controls.
The effect
Each copy of the G allele carried 1.03 times the odds of Mouth ulcers (95% confidence interval 1.02-1.04); p = 2 × 10−8.
How common The G allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 9.5 kb from HLA-E.
What each result means
A/ANo copy of the version the research linked to Mouth ulcers. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Mouth ulcers. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Mouth ulcers. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 30837455 · open access
Questions about rs2429657
What is rs2429657?
rs2429657 is a single position in the genome, in or near the near HLA-E gene. Published research associates it with mouth ulcers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2429657 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2429657 come from?
GWAS Catalog, Nature communications 2019, PMID:30837455. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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