C/CPublished research associates this genotype with typical/baseline likelihood of Broad depression or major depressive disorder (self-reported) — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Broad depression or major depressive disorder (self-reported).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Broad depression or major depressive disorder (self-reported) compared to the general population.
Molecular psychiatry · 2020 · PMID 30626913 · open access
Questions about rs2422320
What is rs2422320?
rs2422320 is a single position in the genome, in or near the NEGR1 gene. Published research associates it with broad depression or major depressive disorder (self-reported). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2422320 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs2422320 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2422320 come from?
GWAS Catalog, Mol Psychiatry 2019, PMID:30626913. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.