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Who was studied 401 European ancestry cases, 17,164 European ancestry controls, 23 African American ancestry cases, 352 African American ancestry controls, 257 Pakistani ancestry cases, 4,453 Pakistani ancestry controls.
The effect
Each copy of the T allele carried 2.78 times the odds of Ischemic stroke (large artery atherosclerosis) (95% confidence interval 1.96-4.00); p = 3 × 10−8.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What each result means
C/CNo copy of the version the research linked to Ischemic stroke (large artery atherosclerosis). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Ischemic stroke (large artery atherosclerosis). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Ischemic stroke (large artery atherosclerosis). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2417957 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with ischemic stroke (large artery atherosclerosis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs2417957 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs2417957 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2417957 come from?
GWAS Catalog, Stroke 2016, PMID:26732560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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