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Who was studied 13,708 European ancestry cases, 95,282 European ancestry controls; replicated in 5,353 European ancestry cases, 5,551 European ancestry controls.
The effect
Each copy of the A allele carried 1.11 times the odds of Parkinson's disease (95% confidence interval 1.08-1.14); p = 1 × 10−11.
How common The A allele had a frequency of about 73% in the people studied.
Where it sits Chromosome 15, band 15q22.2 — inside LOC107984782.
What each result means
A/ATwo copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
Nature genetics · 2014 · PMID 25064009 · open access
Questions about rs2414739
What is rs2414739?
rs2414739 is a single position in the genome, in or near the VPS13C gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2414739 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2414739 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2414739 come from?
GWAS Catalog, Nat Genet 2014, PMID:25064009. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 4642126124123Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity2Meta AI6Microsoft · Copilot1Amazon2Apple4China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others23Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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