Gene Knowledge Graph
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Sensitive

Lung cancer

near COPS2 · rs2413932

Where this position leads

Condition: Lung Cancer

rs2413932 Condition: Lung Cancer Lung Cancer Condition rs2413932 rs2413932 near COPS2

What the study found

Who was studied 26,683 European ancestry cases, 25,278 European ancestry controls, 7,062 East Asian ancestry cases, 5,372 East Asian ancestry controls, 1,987 African American cases, 3,774 African American controls; replicated in 11,680 European ancestry cases, 898,929 European ancestry controls, 13,316 East Asian ancestry cases, 13,324 East Asian ancestry controls, 319 African American cases, 560 African American controls.

The effect Each copy of the T allele shifted the measure 0.08 higher (95% confidence interval 0.06-0.1); p = 7 × 10−20.

Where it sits Chromosome 15, band 15q21.1 — between genes, 14.8 kb from COPS2.

What each result means

C/C No copy of the version the research linked to Lung cancer. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Lung cancer. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Lung cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z
and 73 more — show all
Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov I, Gorlova O, Zhu D, Rosenberg SM, Pinney S, Bailey-Wilson JE, Mandal D, de Andrade M, Gaba C, Willey JC, You M, Anderson M, Wiencke JK, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojeson S, Brenner H, Landi MT, Chanock SJ, Johansson M, Muley T, Risch A, Wichmann HE, Bickeböller H, Christiani DC, Rennert G, Arnold S, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Andrew AS, Kiemeney LA, Shen H, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Cox A, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Patel A, Lan Q, Rothman N, Taylor F, Kachuri L, Witte JS, Sakoda LC, Spitz M, Brennan P, Lin X, McKay J, Hung RJ, Amos CI
Nature genetics · 2022 · PMID 35915169

Questions about rs2413932

What is rs2413932?

rs2413932 is a single position in the genome, in or near the near COPS2 gene. Published research associates it with lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2413932 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs2413932 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2413932 come from?

GWAS Catalog, Nature genetics 2022, PMID:35915169. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung cancer (rs2413932). MyGeneLog™. https://www.mygenelog.com/variants/rs2413932

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