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Smoking initiation (ever regular vs never regular)

REV3L · rs240963

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

rs240963 Condition: Smoking Behaviour and Nicotine Dependence Smoking Behaviour and Nicotine Dependence Condition rs240963 rs240963 REV3L

What the study found

Who was studied up to 433,216 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0265 lower (95% confidence interval 0.02-0.033); p = 2 × 10−17.

How common The C allele had a frequency of about 84% in the people studied.

Where it sits Chromosome 6, band 6q21 — in an intron of REV3L.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking initiation (ever regular vs never regular) compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking initiation (ever regular vs never regular).
T/T Published research associates this genotype with typical/baseline likelihood of Smoking initiation (ever regular vs never regular) — no copies of the reported risk allele.
Source
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD, Liu M, Barnes DR, Bertelsen S, Chou YL
and 59 more — show all
Erzurumluoglu AM, Faul JD, Haessler J, Hammerschlag AR, Hsu C, Kapoor M, Lai D, Le N, de Leeuw CA, Loukola A, Mangino M, Melbourne CA, Pistis G, Qaiser B, Rohde R, Shao Y, Stringham H, Wetherill L, Zhao W, Agrawal A, Bierut L, Chen C, Eaton CB, Goate A, Haiman C, Heath A, Iacono WG, Martin NG, Polderman TJ, Reiner A, Rice J, Schlessinger D, Scholte HS, Smith JA, Tardif JC, Tindle HA, van der Leij AR, Boehnke M, Chang-Claude J, Cucca F, David SP, Foroud T, Howson JMM, Kardia SLR, Kooperberg C, Laakso M, Lettre G, Madden P, McGue M, North K, Posthuma D, Spector T, Stram D, Tobin MD, Weir DR, Kaprio J, Abecasis GR, Liu DJ, Vrieze S
CHD Exome+ Consortium · Consortium for Genetics of Smoking Behaviour
Biological psychiatry · 2019 · PMID 30679032

Questions about rs240963

What is rs240963?

rs240963 is a single position in the genome, in or near the REV3L gene. Published research associates it with smoking initiation (ever regular vs never regular). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs240963 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does having rs240963 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs240963 come from?

GWAS Catalog, Biol Psychiatry 2018, PMID:30679032. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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