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Who was studied 397,338 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0139 lower (95% confidence interval 0.0095-0.0182); p = 4 × 10−10.
How common The C allele had a frequency of about 69% in the people studied.
Where it sits Chromosome 5, band 5q21.3 — in an intron of EFNA5.
What each result means
C/CTwo copies of the version the research linked to Age at first sexual intercourse. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Age at first sexual intercourse. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Age at first sexual intercourse. This is the starting point the study compared everyone against.
Nature human behaviour · 2021 · PMID 34211149 · open access
Questions about rs2406374
What is rs2406374?
rs2406374 is a single position in the genome, in or near the EFNA5 gene. Published research associates it with age at first sexual intercourse. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2406374 linked to?
On MyGeneLog this position is linked to Age at First Sexual Intercourse. The research behind each link, and its sources, are set out on that condition page.
Does having rs2406374 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2406374 come from?
GWAS Catalog, Nature human behaviour 2021, PMID:34211149. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7214Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Age at first sexual intercourse (rs2406374). MyGeneLog™. https://www.mygenelog.com/variants/rs2406374