Sensitive

Lung cancer or family history of lung cancer

CEP43 · rs239933

Where this position leads

Condition: Lung Cancer

rs239933 Condition: Lung Cancer Lung Cancer Condition rs239933 rs239933 CEP43

What the study found

Who was studied 29,266 European ancestry lung cancer cases, 48,843 European ancestry individuals with family history of lung cancer, 251,837 European ancestry controls.

The effect Each copy of the G allele carried 0.94 times the odds of Lung cancer or family history of lung cancer (95% confidence interval 0.921-0.957); p = 7 × 10−12.

How common The G allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 6, band 6q27 — in an intron of CEP43.

What each result means

A/A No copy of the version the research linked to Lung cancer or family history of lung cancer. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Lung cancer or family history of lung cancer. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Lung cancer or family history of lung cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs239933

What is rs239933?

rs239933 is a single position in the genome, in or near the CEP43 gene. Published research associates it with lung cancer or family history of lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs239933 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs239933 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs239933 come from?

GWAS Catalog, Journal of the National Cancer Institute 2022, PMID:35511172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Lung cancer or family history of lung cancer (rs239933). MyGeneLog™. https://www.mygenelog.com/variants/rs239933

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