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Who was studied 163,015 European ancestry, African American, Asian ancestry, Hispanic or Latin American and unknown ancestry individuals.
The effect
Each copy of the A allele carried 1.06 times the odds of Osteoarthritis (95% confidence interval 1.04-1.08); p = 1 × 10−13.
How common The A allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 7, band 7q31.1 — in an intron of FOXP2.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Osteoarthritis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Osteoarthritis. This is the starting point the study compared everyone against.
rs2396724 is a single position in the genome, in or near the FOXP2 gene. Published research associates it with osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2396724 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs2396724 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2396724 come from?
GWAS Catalog, Nature genetics 2022, PMID:36411363. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 12237Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others7Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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