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Chronotype

FOXP2 · rs2396719

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 449,734 European ancestry individuals; replicated in 248,098 European ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 1 × 10−12.

How common The A allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 7, band 7q31.1 — in an intron of FOXP2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronotype compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronotype.
G/G Published research associates this genotype with typical/baseline likelihood of Chronotype — no copies of the reported risk allele.
Source
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H
and 20 more — show all
Sharp SA, Jie Y, Thompson WD, Harrison JW, Dawes A, Byrne EM, Tiemeier H, Allebrandt KV, Bowden J, Ray DW, Freathy RM, Murray A, Mazzotti DR, Gehrman PR, Lawlor DA, Frayling TM, Rutter MK, Hinds DA, Saxena R, Weedon MN
Nature communications · 2019 · PMID 30696823 · open access

Questions about rs2396719

What is rs2396719?

rs2396719 is a single position in the genome, in or near the FOXP2 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2396719 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2396719 come from?

GWAS Catalog, Nature communications 2019, PMID:30696823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronotype (rs2396719). MyGeneLog™. https://www.mygenelog.com/variants/rs2396719

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