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Leukocyte telomere length

PRAM1 · rs2396106

What the study found

Who was studied 327,790 British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.013 higher (95% confidence interval 0.0091-0.0169); p = 2 × 10−8.

How common The G allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 19, band 19p13.2 — in an intron of PRAM1.

What each result means

G/G Two copies of the version the research linked to Leukocyte telomere length. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Leukocyte telomere length. That is a smaller link than two copies.
T/T No copy of the version the research linked to Leukocyte telomere length. This is the starting point the study compared everyone against.
Source

Questions about rs2396106

What is rs2396106?

rs2396106 is a single position in the genome, in or near the PRAM1 gene. Published research associates it with leukocyte telomere length. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2396106 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2396106 come from?

GWAS Catalog, GeroScience 2024, PMID:38837026. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Leukocyte telomere length (rs2396106). MyGeneLog™. https://www.mygenelog.com/variants/rs2396106

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