Standard

QRS duration

SPRK1 · rs2395642

Where this position leads

Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration)

rs2395642 Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration) Cardiac Conduction Intervals (PR In… Condition rs2395642 rs2395642 SPRK1

What the study found

Who was studied 15,124 Hispanic or Latin American individuals.

The effect Each copy of the T allele shifted the measure 0.93 ms higher (95% confidence interval 0.68-1.18); p = 5 × 10−9.

How common The T allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 6, band 6p21.31 — in an intron of SRPK1.

What each result means

C/C No copy of the version the research linked to QRS duration. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to QRS duration. That is a smaller link than two copies.
T/T Two copies of the version the research linked to QRS duration. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2395642

What is rs2395642?

rs2395642 is a single position in the genome, in or near the SPRK1 gene. Published research associates it with qrs duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2395642 linked to?

On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.

Does having rs2395642 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2395642 come from?

GWAS Catalog, PloS one 2019, PMID:31251759. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

QRS duration (rs2395642). MyGeneLog™. https://www.mygenelog.com/variants/rs2395642

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