HNF1A · rs2393791
Where this position leads
Conditions: C-Reactive Protein Levels, Blood Cell Counts
Strength of the evidence
Its strongest genetic-study result is p = 10−125, with 23 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 8,722 individuals.
The effect Each copy of the C allele shifted the measure 0.049 mg/dl lower; p = 3 × 10−9.
How common The C allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 12, band 12q24.31 — in an intron of HNF1A.
How common each version is
CT
C 47.9% · T 52.1%
C 48.1% · T 51.9%
C 47.6% · T 52.4%
C 36.8% · T 63.2%
C 38.5% · T 61.5%
C 40.6% · T 59.4%
C 37.9% · T 62.2%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs2393791 is a single position in the genome, in or near the HNF1A gene. Published research associates it with c-reactive protein and white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to C-Reactive Protein Levels, Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Int J Immunogenet 2012, PMID:22788528. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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C-reactive protein and white blood cell count (rs2393791). MyGeneLog™. https://www.mygenelog.com/variants/rs2393791