Standard

Body mass index

STK39 · rs2390669

Where this position leads

What the study found

Who was studied up to 72,390 Japanese ancestry women, up to 85,894 Japanese ancestry men; replicated in up to 10,048 Japanese ancestry women, up to 5,098 Japanese ancestry men, up to 181,999 European ancestry women, up to 140,155 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.021 higher (95% confidence interval 0.015-0.027); p = 2 × 10⁻¹⁰.

How common The C allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 2, band 2q24.3 — in an intron of STK39.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.

Source

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T

and 10 more — show all

Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M, Kamatani Y

Nature genetics · 2017 · PMID 28892062

Questions about rs2390669

What is rs2390669?

rs2390669 is a single position in the genome, in or near the STK39 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2390669 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs2390669 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2390669 come from?

GWAS Catalog, Nat Genet 2017, PMID:28892062. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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