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Sensitive

Depression

near HMGB1P18 · rs2389015

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

rs2389015 Condition: Endometriosis and Depression: Shared Genetics Endometriosis and Depression: Share… Condition rs2389015 rs2389015 near HMGB1P18

What the study found

Who was studied 371,184 European ancestry cases, 978,703 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0218 lower (95% confidence interval 0.016-0.028); p = 2 × 10−12.

How common The G allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 1, band 1p31.1 — between genes, 49.5 kb from HMGB1P18.

What each result means

A/A No copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Depression. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses
Als TD, Kurki MI, Grove J, Voloudakis G, Therrien K, Tasanko E, Nielsen TT, Naamanka J, Veerapen K, Levey DF, Bendl J, Bybjerg-Grauholm J
and 31 more — show all
Zeng B, Demontis D, Rosengren A, Athanasiadis G, Bækved-Hansen M, Qvist P, Bragi Walters G, Thorgeirsson T, Stefánsson H, Musliner KL, Rajagopal VM, Farajzadeh L, Thirstrup J, Vilhjálmsson BJ, McGrath JJ, Mattheisen M, Meier S, Agerbo E, Stefánsson K, Nordentoft M, Werge T, Hougaard DM, Mortensen PB, Stein MB, Gelernter J, Hovatta I, Roussos P, Daly MJ, Mors O, Palotie A, Børglum AD
Nature medicine · 2023 · PMID 37464041

Questions about rs2389015

What is rs2389015?

rs2389015 is a single position in the genome, in or near the near HMGB1P18 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2389015 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs2389015 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2389015 come from?

GWAS Catalog, Nature medicine 2023, PMID:37464041. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depression (rs2389015). MyGeneLog™. https://www.mygenelog.com/variants/rs2389015

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