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Who was studied 7,699 Chinese ancestry cases, 35,476 European ancestry cases, 18,327 Chinese ancestry controls, 46,839 European ancestry controls; replicated in 4,384 Chinese ancestry cases, 5,770 Chinese ancestry controls.
The effect
Each copy of the T allele carried 1.08 times the odds of Schizophrenia (95% confidence interval 1.05-1.1); p = 9 × 10−9.
Where it sits Chromosome 2, band 2q22.3 — between genes, 155.8 kb from METAP2P1.
What each result means
A/ANo copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2381759 is a single position in the genome, in or near the TEX41 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2381759 linked to?
On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.
Does having rs2381759 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2381759 come from?
GWAS Catalog, Nature genetics 2017, PMID:28991256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 11425Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot4Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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