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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 305 European ancestry cognitively normal individuals.
The effect
Each copy of the T allele shifted the measure 0.53 lower (95% confidence interval 0.33-0.73); p = 2 × 10−8.
How common The T allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 17, band 17q23.2 — between genes, 19.3 kb from NACA2.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Cerebrospinal AB1-42 levels in normal cognition — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cerebrospinal AB1-42 levels in normal cognition.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cerebrospinal AB1-42 levels in normal cognition compared to the general population.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018 · PMID 29274321
Questions about rs2378873
What is rs2378873?
rs2378873 is a single position in the genome, in or near the NACA2 gene. Published research associates it with cerebrospinal ab1-42 levels in normal cognition. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2378873 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2378873 come from?
GWAS Catalog, Alzheimers Dement 2017, PMID:29274321. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cerebrospinal AB1-42 levels in normal cognition (rs2378873). MyGeneLog™. https://www.mygenelog.com/variants/rs2378873