Sensitive

Breast cancer (estrogen-receptor positive)

TESHL · rs2372943

Where this position leads

Condition: Breast Cancer

rs2372943 Condition: Breast Cancer Breast Cancer Condition rs2372943 rs2372943 TESHL

What the study found

Who was studied 9,304 African or African American cases, 19,024 African or African American controls.

The effect Each copy of the G allele carried 1.21 times the odds of Breast cancer (estrogen-receptor positive) (95% confidence interval 1.14-1.28); p = 3 × 10−11.

How common The G allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 2, band 2q35 — in an intron of TESHL.

What each result means

A/A No copy of the version the research linked to Breast cancer (estrogen-receptor positive). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Breast cancer (estrogen-receptor positive). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Breast cancer (estrogen-receptor positive). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2372943

What is rs2372943?

rs2372943 is a single position in the genome, in or near the TESHL gene. Published research associates it with breast cancer (estrogen-receptor positive). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2372943 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs2372943 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2372943 come from?

GWAS Catalog, Nature genetics 2024, PMID:38741014. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Breast cancer (estrogen-receptor positive) (rs2372943). MyGeneLog™. https://www.mygenelog.com/variants/rs2372943

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