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Blood protein levels

NRXN3 · rs2370901

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹³, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 3,200 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.189 higher (95% confidence interval 0.14-0.24); p = 6 × 10⁻¹⁴.

How common The T allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 14, band 14q31.1 — in an intron of NRXN3.

What each result means

C/C No copy of the version the research linked to Blood protein levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Blood protein levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Blood protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Co-regulatory networks of human serum proteins link genetics to disease

Emilsson V, Ilkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Gudmundsdottir V, Horman SR, Horman SR, Aspelund T, Shu L

and 17 more — show all

Trifonov V, Sigurdsson S, Manolescu A, Zhu J, Olafsson Ö, Jakobsdottir J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Orth AP, Jennings LL, Gudnason V

Science (New York, N.Y.) · 2018 · PMID 30072576

Questions about rs2370901

What is rs2370901?

rs2370901 is a single position in the genome, in or near the NRXN3 gene. Published research associates it with blood protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2370901 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2370901 come from?

GWAS Catalog, Science (New York, N.Y.) 2018, PMID:30072576. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Blood protein levels (rs2370901). MyGeneLog™. https://www.mygenelog.com/variants/rs2370901

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