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Who was studied 346 European ancestry cases, 727 European ancestry controls; replicated in 185 European ancestry cases, 340 European ancestry controls.
The effect
Each copy of the A allele carried 1.87 times the odds of Type 1 diabetes and autoimmune thyroid diseases; p = 2 × 10−11.
Where it sits Chromosome 1, band 1p13.2 — in an intron of AP4B1-AS1.
What each result means
A/ATwo copies of the version the research linked to Type 1 diabetes and autoimmune thyroid diseases. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Type 1 diabetes and autoimmune thyroid diseases. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Type 1 diabetes and autoimmune thyroid diseases. This is the starting point the study compared everyone against.
rs2358994 is a single position in the genome, in or near the BCL2L15 gene. Published research associates it with type 1 diabetes and autoimmune thyroid diseases. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2358994 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs2358994 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2358994 come from?
GWAS Catalog, J Autoimmun 2015, PMID:25936594. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 29321522212Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity1Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others12Total29Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes and autoimmune thyroid diseases (rs2358994). MyGeneLog™. https://www.mygenelog.com/variants/rs2358994