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Cortical surface area

near CDKN3 · rs2358483

What the study found

Who was studied 33,992 European ancestry individuals; replicated in 14,727 European ancestry individuals, 2,943 individuals.

The effect Each copy of the T allele shifted the measure 12.1 lower (95% confidence interval 9.15-14.96); p = 4 × 10−16.

How common The T allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 14, band 14q22.2 — between genes, 139.5 kb from CDKN3.

What each result means

C/C No copy of the version the research linked to Cortical surface area. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cortical surface area. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cortical surface area. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2358483

What is rs2358483?

rs2358483 is a single position in the genome, in or near the near CDKN3 gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2358483 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2358483 come from?

GWAS Catalog, Science (New York, N.Y.) 2020, PMID:32193296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cortical surface area (rs2358483). MyGeneLog™. https://www.mygenelog.com/variants/rs2358483

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