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Who was studied 20,427 African ancestry individuals; replicated in Up to 16,436 African American individuals.
The effect
Each copy of the T allele shifted the measure 0.057 higher (95% confidence interval 0.037-0.077); p = 2 × 10−9.
How common The T allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 15, band 15q26.1 — a synonymous change in ACAN.
What ClinVar records
ClassificationBenign for Osteochondritis dissecans, Spondyloepimetaphyseal dysplasia, aggrecan type, Spondyloepiphyseal dysplasia, Kimberley type; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2026-05-08.
ClinVar record 1181962NM_001369268.1(ACAN):c.2289C>T (p.Pro763=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Height. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Height. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
PLoS genetics · 2011 · PMID 21998595 · open access
Questions about rs2351491
What is rs2351491?
rs2351491 is a single position in the genome, in or near the ACAN gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2351491 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs2351491 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2351491 come from?
GWAS Catalog, PLoS Genet 2011, PMID:21998595. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 5042126123227Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity2Meta AI6Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total50Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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