Standard
Lymphocyte count
FMNL2 · rs2345872
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 643,370 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals.
The effect
The reported allele is C; the catalogue records no effect size
; p = 1 × 10−12.
How common The C allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 2, band 2q23.3 — in an intron of FMNL2.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lymphocyte count compared to the general population.
C/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lymphocyte count.
G/G
Published research associates this genotype with typical/baseline likelihood of Lymphocyte count — no copies of the reported risk allele.
Source
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
Chen MH,
Raffield LM,
Mousas A,
Sakaue S,
Huffman JE,
Moscati A,
Trivedi B,
Jiang T,
Akbari P,
Vuckovic D,
Bao EL,
Zhong X
and 98 more — show all
Manansala R,
Laplante V,
Chen M,
Lo KS,
Qian H,
Lareau CA,
Beaudoin M,
Hunt KA,
Akiyama M,
Bartz TM,
Ben-Shlomo Y,
Beswick A,
Bork-Jensen J,
Bottinger EP,
Brody JA,
van Rooij FJA,
Chitrala K,
Cho K,
Choquet H,
Correa A,
Danesh J,
Di Angelantonio E,
Dimou N,
Ding J,
Elliott P,
Esko T,
Evans MK,
Floyd JS,
Broer L,
Grarup N,
Guo MH,
Greinacher A,
Haessler J,
Hansen T,
Howson JMM,
Huang QQ,
Huang W,
Jorgenson E,
Kacprowski T,
Kähönen M,
Kamatani Y,
Kanai M,
Karthikeyan S,
Koskeridis F,
Lange LA,
Lehtimäki T,
Lerch MM,
Linneberg A,
Liu Y,
Lyytikäinen LP,
Manichaikul A,
Martin HC,
Matsuda K,
Mohlke KL,
Mononen N,
Murakami Y,
Nadkarni GN,
Nauck M,
Nikus K,
Ouwehand WH,
Pankratz N,
Pedersen O,
Preuss M,
Psaty BM,
Raitakari OT,
Roberts DJ,
Rich SS,
Rodriguez BAT,
Rosen JD,
Rotter JI,
Schubert P,
Spracklen CN,
Surendran P,
Tang H,
Tardif JC,
Trembath RC,
Ghanbari M,
Völker U,
Völzke H,
Watkins NA,
Zonderman AB,
Wilson PWF,
Li Y,
Butterworth AS,
Gauchat JF,
Chiang CWK,
Li B,
Loos RJF,
Astle WJ,
Evangelou E,
van Heel DA,
Sankaran VG,
Okada Y,
Soranzo N,
Johnson AD,
Reiner AP,
Auer PL,
Lettre G
Cell · 2020 · PMID 32888493
Questions about rs2345872
What is rs2345872?
rs2345872 is a single position in the genome, in or near the FMNL2 gene. Published research associates it with lymphocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2345872 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2345872 come from?
GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lymphocyte count (rs2345872). MyGeneLog™. https://www.mygenelog.com/variants/rs2345872
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