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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 134,070 European ancestry individuals, 143,658 East Asian ancestry individuals, 26,344 Hispanic or Latino ancestry individuals, 8,224 African American individuals.
The effect
Each copy of the C allele shifted the measure 0.416 ml/min/1.73m2 lower (95% confidence interval 0.15-0.68); p = 2 × 10−10.
How common The C allele had a frequency of about 11% in the people studied.
Where it sits Chromosome 11, band 11p15.5 — in an intron of KCNQ1.
What each result means
C/CTwo copies of the version the research linked to Estimated glomerular filtration rate. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Estimated glomerular filtration rate. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Estimated glomerular filtration rate. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 30604766 · open access
Questions about rs231889
What is rs231889?
rs231889 is a single position in the genome, in or near the H19 gene. Published research associates it with estimated glomerular filtration rate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs231889 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs231889 come from?
GWAS Catalog, Nature communications 2019, PMID:30604766. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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