Thyroid peroxidase antibody positivity in pregnancy
CTLA4 · rs231770
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 10,218 Chinese ancestry cases, 58,843 Chinese ancestry controls.
The effect
Each copy of the C allele carried 0.79 times the odds of Thyroid peroxidase antibody positivity in pregnancy (95% confidence interval 0.76-0.82); p = 9 × 10−40.
How common The C allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 2, band 2q33.2 — in an intron of CTLA4.
What each result means
C/CTwo copies of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39266554 · open access
Questions about rs231770
What is rs231770?
rs231770 is a single position in the genome, in or near the CTLA4 gene. Published research associates it with thyroid peroxidase antibody positivity in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs231770 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs231770 come from?
GWAS Catalog, Nature communications 2024, PMID:39266554. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Thyroid peroxidase antibody positivity in pregnancy (rs231770). MyGeneLog™. https://www.mygenelog.com/variants/rs231770