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Who was studied 2,853 European ancestry cases and 37,405 European ancestry controls; replicated in 1,827 European ancestry cases and 2,181 European ancestry controls.
The effect
Each copy of the A allele carried 1.18 times the odds of Vitiligo (95% confidence interval 1.12-1.24); p = 1 × 10−10.
How common The A allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 2, band 2q33.2 — between genes, 2 kb from CTLA4.
What each result means
A/ATwo copies of the version the research linked to Vitiligo. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Vitiligo. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Vitiligo. This is the starting point the study compared everyone against.
Bujnis MN, et al. (Nature Genetics, 2026) is newly in the GWAS Catalog, with 422 associations across 1 trait ("Hashimoto thyroiditis"). The catalogue records its sample as 47,104 cases and 1,037,695 controls. Of its 299 positions, 93 already have pages here — 20 on the Hypothyroidism page; 20 on the Hashimoto Thyroiditis page; 5 on the Thyroid Stimulating Hormone (TSH) Levels page — including rs3130552 (near PSORS1C1), rs1230666 (MAG13), rs231725 (CTLA4). Everything above is from the catalogue's records, assembled by code; the paper itself is linked. PMID:42527560.
Questions about rs231725
What is rs231725?
rs231725 is a single position in the genome, in or near the CTLA4 gene. Published research associates it with vitiligo. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs231725 linked to?
On MyGeneLog this position is linked to Vitiligo. The research behind each link, and its sources, are set out on that condition page.
Does having rs231725 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs231725 come from?
GWAS Catalog, Nat Genet 2016, PMID:27723757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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