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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 118,780 European ancestry, African ancestry, Hispanic or Latin American individuals.
The effect
Each copy of the T allele shifted the measure 0.076 higher (95% confidence interval 0.058-0.094); p = 6 × 10−17.
How common The T allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 2, band 2q31.2 — a missense change in TTN.
What ClinVar records
ClassificationBenign/Likely benign for Early-onset myopathy with fatal cardiomyopathy, Cardiovascular phenotype, Dilated cardiomyopathy 1G, Myopathy, myofibrillar, 9, with early respiratory failure, Tibial muscular dystrophy and 1 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 15 submitters), last evaluated 2026-02-04.
ClinVar record 47527NM_001267550.2(TTN):c.8492G>A (p.Ser2831Asn)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Spatial QRS-T angle. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Spatial QRS-T angle. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Spatial QRS-T angle. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 36918541 · open access
Questions about rs2306636
What is rs2306636?
rs2306636 is a single position in the genome, in or near the TTN gene. Published research associates it with spatial qrs-t angle. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2306636 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2306636 come from?
GWAS Catalog, Nature communications 2023, PMID:36918541. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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