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Body mass index or knee osteoarthritis (pleiotropy)

PKD1L3 · rs2303220

Where this position leads

Condition: Knee Osteoarthritis

rs2303220 Condition: Knee Osteoarthritis Knee Osteoarthritis Condition rs2303220 rs2303220 PKD1L3

What the study found

Who was studied 806,834 European ancestry BMI individuals, 62,497 European ancestry knee osteoarthritis cases, 333,557 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 1 × 10−13.

Where it sits Chromosome 16, band 16q22.2 — in an intron of PKD1L3.

What each result means

G/G No copy of the version the research linked to Body mass index or knee osteoarthritis (pleiotropy). This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Body mass index or knee osteoarthritis (pleiotropy). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Body mass index or knee osteoarthritis (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses
Zhang L, Zhang W, Wu X, Cui H, Yan P, Yang C, Zhao X, Xiao J, Xiao C, Tang M, Wang Y, Chen L
and 10 more — show all
Liu Y, Zou Y, Zhang L, Yang Y, Yao Y, Li J, Liu Z, Yang C, Zhang B, Jiang X
Osteoarthritis and cartilage · 2023 · PMID 36889626

Questions about rs2303220

What is rs2303220?

rs2303220 is a single position in the genome, in or near the PKD1L3 gene. Published research associates it with body mass index or knee osteoarthritis (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2303220 linked to?

On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs2303220 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2303220 come from?

GWAS Catalog, Osteoarthritis and cartilage 2023, PMID:36889626. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index or knee osteoarthritis (pleiotropy) (rs2303220). MyGeneLog™. https://www.mygenelog.com/variants/rs2303220

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