OLFM2 · rs2303100
Where this position leads
Condition: Sleep and Circadian Rhythm
What the study found
Who was studied 91,105 European ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.03 SD units lower (95% confidence interval 0.02-0.04); p = 1 × 10−10.
How common The C allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 19, band 19p13.2 — a missense change in OLFM2.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-12.
ClinVar record 1297260 NM_058164.4(OLFM2):c.317G>A (p.Arg106Gln)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2303100 is a single position in the genome, in or near the OLFM2 gene. Published research associates it with sleep duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Commun 2018, PMID:30531941. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Sleep duration (rs2303100). MyGeneLog™. https://www.mygenelog.com/variants/rs2303100