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Red vs. brown/black hair color

TUBB3 · rs2302898

Where this position leads

Condition: Hair Color

What the study found

Who was studied 15,731 British ancestry red hair individuals, 283,920 British ancestry brown or black hair individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 3 × 10⁻¹⁰³.

How common The A allele had a frequency of about 29% in the people studied.

Where it sits Chromosome 16, band 16q24.3 — in an intron of TUBB3.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-06-14. ClinVar record 670258 NM_006086.4(TUBB3):c.58-185G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Red vs. brown/black hair color. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Red vs. brown/black hair color. That is a smaller link than two copies.

G/G No copy of the version the research linked to Red vs. brown/black hair color. This is the starting point the study compared everyone against.

Source

Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability

Morgan MD, Pairo-Castineira E, Rawlik K, Canela-Xandri O, Rees J, Sims D, Tenesa A, Jackson IJ

Nature communications · 2018 · PMID 30531825 · open access

Questions about rs2302898

What is rs2302898?

rs2302898 is a single position in the genome, in or near the TUBB3 gene. Published research associates it with red vs. brown/black hair color. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2302898 linked to?

On MyGeneLog this position is linked to Hair Color. The research behind each link, and its sources, are set out on that condition page.

Does having rs2302898 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2302898 come from?

GWAS Catalog, Nature communications 2018, PMID:30531825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Red vs. brown/black hair color (rs2302898). MyGeneLog™. https://www.mygenelog.com/variants/rs2302898

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