Sensitive

Restless legs syndrome

MEIS1 · rs2300478

Where this position leads

What the study found

Who was studied 401 European ancestry cases, 1,644 European ancestry controls; replicated in 906 European ancestry cases, 891 European ancestry controls, 255 French Canadian cases, 287 French Canadian controls.

The effect Each copy of the G allele carried 1.74 times the odds of Restless legs syndrome (95% confidence interval 1.57-1.92); p = 3 × 10⁻²⁸.

How common The G allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 2, band 2p14 — in an intron of MEIS1.

What each result means

G/G Two copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.

T/T No copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.

Source

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A

and 15 more — show all

Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T

Nature genetics · 2007 · PMID 17637780

What people read about alongside this

Sleep and insomnia1 ADHD and attention1 Kidneys1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

From our blog

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Questions about rs2300478

What is rs2300478?

rs2300478 is a single position in the genome, in or near the MEIS1 gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2300478 linked to?

On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs2300478?

Subjects that appear in the title or abstract of the same papers as this rsID include sleep and insomnia (1 papers), adhd and attention (1 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2300478 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2300478 come from?

GWAS Catalog, Nat Genet 2007, PMID:17637780. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Restless legs syndrome (rs2300478). MyGeneLog™. https://www.mygenelog.com/variants/rs2300478

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