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Glycated hemoglobin HbA1c levels

KCNQ1 · rs2299620

What the study found

Who was studied 4,911 Japanese ancestry individuals; replicated in 48,694 Japanese ancestry individuals.

The effect Each copy of the T allele shifted the measure 12.5 z score lower; p = 1 × 10−35.

Where it sits Chromosome 11, band 11p15.4 — in an intron of KCNQ1.

What each result means

C/C No copy of the version the research linked to Glycated hemoglobin HbA1c levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Glycated hemoglobin HbA1c levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Glycated hemoglobin HbA1c levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2299620

What is rs2299620?

rs2299620 is a single position in the genome, in or near the KCNQ1 gene. Published research associates it with glycated hemoglobin hba1c levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2299620 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2299620 come from?

GWAS Catalog, Diabetology international 2023, PMID:37090135. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Glycated hemoglobin HbA1c levels (rs2299620). MyGeneLog™. https://www.mygenelog.com/variants/rs2299620

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