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Atrial fibrillation

NEBL · rs2296610

Where this position leads

What the study found

Who was studied 8,180 Japanese ancestry cases, 28,612 Japanese ancestry controls; replicated in 3,120 Japanese ancestry cases, 125,064 Japanese ancestry controls, 15,993 European ancestry cases, 113,719 European ancestry controls.

The effect Each copy of the T allele carried 1.20 times the odds of Atrial fibrillation (95% confidence interval 1.141-1.251); p = 2 × 10⁻¹⁴.

How common The T allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 10, band 10p12.31 — a missense change in NEBL.

What ClinVar records

Classification Benign/Likely benign for Primary dilated cardiomyopathy, Cardiovascular phenotype, NEBL-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 7 submitters), last evaluated 2026-02-03. ClinVar record 45500 NM_006393.3(NEBL):c.656C>A (p.Ala219Asp)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M

and 10 more — show all

Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka T

AFGen Consortium

Nature genetics · 2017 · PMID 28416822

Questions about rs2296610

What is rs2296610?

rs2296610 is a single position in the genome, in or near the NEBL gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2296610 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs2296610 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2296610 come from?

GWAS Catalog, Nat Genet 2017, PMID:28416822. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs2296610). MyGeneLog™. https://www.mygenelog.com/variants/rs2296610

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