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Who was studied 129,270 European ancestry cases, 108,357 European ancestry controls; replicated in 17,140 European ancestry cases, 61,850 European ancestry controls.
The effect
Each copy of the G allele carried 1.03 times the odds of Insomnia symptoms (never/rarely vs. usually) (95% confidence interval 1.01-1.04); p = 4 × 10−11.
How common The G allele had a frequency of about 70% in the people studied.
Where it sits Chromosome 10, band 10q24.32 — at a splice region of ACTR1A.
What each result means
G/GTwo copies of the version the research linked to Insomnia symptoms (never/rarely vs. usually). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Insomnia symptoms (never/rarely vs. usually). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Insomnia symptoms (never/rarely vs. usually). This is the starting point the study compared everyone against.
Nature genetics · 2019 · PMID 30804566 · open access
Questions about rs2296580
What is rs2296580?
rs2296580 is a single position in the genome, in or near the ACTR1A gene. Published research associates it with insomnia symptoms (never/rarely vs. usually). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2296580 linked to?
On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.
Does having rs2296580 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2296580 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804566. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Insomnia symptoms (never/rarely vs. usually) (rs2296580). MyGeneLog™. https://www.mygenelog.com/variants/rs2296580