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Who was studied 2,628 Chinese ancestry cases, 11,563 Chinese ancestry controls; replicated in 6,879 Han Chinese ancestry cases, 9,019 Han Chinese ancestry controls, 1,039 Italian ancestry cases, 1,289 Italian ancestry controls.
The effect
Each copy of the T allele carried 1.36 times the odds of IgA nephropathy (95% confidence interval 1.25664462393162-1.47311444258073); p = 3 × 10−14.
How common The T allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — in a non-coding transcript of HLA-DPA2.
What each result means
G/GNo copy of the version the research linked to IgA nephropathy. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to IgA nephropathy. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to IgA nephropathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of the American Society of Nephrology : JASN · 2020 · PMID 32912934
Questions about rs2295119
What is rs2295119?
rs2295119 is a single position in the genome, in or near the DPA1.DPB2 gene. Published research associates it with iga nephropathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2295119 linked to?
On MyGeneLog this position is linked to IgA Nephropathy. The research behind each link, and its sources, are set out on that condition page.
Does having rs2295119 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2295119 come from?
GWAS Catalog, Journal of the American Society of Nephrology : JASN 2020, PMID:32912934. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
IgA nephropathy (rs2295119). MyGeneLog™. https://www.mygenelog.com/variants/rs2295119