0 2012112328Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 60,552 European ancestry individuals, 8,429 African individuals, 9,959 Korean ancestry individuals, 11,775 Hispanic individuals.
The effect
Each copy of the T allele shifted the measure 0.002 higher (95% confidence interval 0.0012-0.0028); p = 2 × 10−8.
How common The T allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 10, band 10q26.13 — in an intron of HTRA1.
What ClinVar records
ClassificationBenign for Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 2, Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2021-08-10.
ClinVar record 1259856NM_002775.5(HTRA1):c.1275-36C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Lung function (FEV1/FVC). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Lung function (FEV1/FVC). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Lung function (FEV1/FVC). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 30061609 · open access
Questions about rs2293871
What is rs2293871?
rs2293871 is a single position in the genome, in or near the HTRA1 gene. Published research associates it with lung function (fev1/fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2293871 linked to?
On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.
Does having rs2293871 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2293871 come from?
GWAS Catalog, Nat Commun 2018, PMID:30061609. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2012112328Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung function (FEV1/FVC) (rs2293871). MyGeneLog™. https://www.mygenelog.com/variants/rs2293871