0 3432136223210Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others10Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 60,620 European ancestry cases, 970,216 European ancestry controls.
The effect
Each copy of the G allele carried 1.09 times the odds of Atrial fibrillation (95% confidence interval 1.07-1.12); p = 2 × 10−17.
How common The G allele had a frequency of about 10% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in a non-coding transcript of SOX5.
What each result means
G/GTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
rs2291437 is a single position in the genome, in or near the LINC00477 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2291437 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs2291437 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2291437 come from?
GWAS Catalog, Nat Genet 2018, PMID:30061737. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 3432136223210Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others10Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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