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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
2 / 4
Its strongest genetic-study result is p = 10−22, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 408,112 British individuals.
The effect
Each copy of the G allele shifted the measure 0.0271 higher (95% confidence interval 0.022-0.033); p = 2 × 10−22.
How common The G allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 22, band 22q12.3 — in an intron of TMPRSS6.
How common each version is
AG
KoreanKRGDB
A 48.4% · G 51.6%
KoreanKorea4K
A 47.2% · G 52.8%
KoreanKorea1K
A 46.4% · G 53.6%
Japanese ToMMo
A 43.5% · G 56.5%
Vietnamese
A 54.3% · G 45.7%
World gnomAD
A 41.1% · G 58.9%
World 1000 Genomes
A 47.3% · G 52.7%
World TOPMed
A 40.7% · G 59.3%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ANo copy of the version the research linked to Red cell distribution width. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Red cell distribution width. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Red cell distribution width. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs228910 is a single position in the genome, in or near the TMPRSS6 gene. Published research associates it with red cell distribution width. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs228910 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs228910 come from?
GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 152238Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others8Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Red cell distribution width (rs228910). MyGeneLog™. https://www.mygenelog.com/variants/rs228910