1 251522114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI5Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others14Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 98,805 European ancestry cases, 948,186 European ancestry controls, 14,588 cases, 117,082 controls; replicated in 34,835 European ancestry cases, 492,149 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.061 lower (95% confidence interval 0.051-0.071); p = 1 × 10−31.
How common The A allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 5, band 5q21.1 — in an intron of MACIR.
What each result means
A/ATwo copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 41238958 · open access
Questions about rs2288786
What is rs2288786?
rs2288786 is a single position in the genome, in or near the MACIR gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2288786 linked to?
On MyGeneLog this position is linked to Hypothyroidism, Thyroid Stimulating Hormone (TSH) Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs2288786 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2288786 come from?
GWAS Catalog, Nature genetics 2025, PMID:41238958. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 251522114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI5Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others14Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.