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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 434,835 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.03 lower (95% confidence interval 0.022-0.038); p = 3 × 10−16.
How common The A allele had a frequency of about 10% in the people studied.
Where it sits Chromosome 1, band 1p36.23 — in an intron of PER3.
What each result means
A/ATwo copies of the version the research linked to Morningness. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Morningness. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Morningness. This is the starting point the study compared everyone against.
rs228654 is a single position in the genome, in or near the PER3 gene. Published research associates it with morningness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs228654 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs228654 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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