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Who was studied 4,376 European ancestry cases, 345,887 European ancestry controls; replicated in 5,598 European ancestry cases, 15,261 European ancestry controls.
The effect
Each copy of the T allele carried 1.17 times the odds of Multiple myeloma; p = 1 × 10−11.
How common The T allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in an intron of PSORS1C1.
What each result means
C/CNo copy of the version the research linked to Multiple myeloma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Multiple myeloma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Multiple myeloma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Blood cancer journal · 2021 · PMID 33875642 · open access
Questions about rs2285803
What is rs2285803?
rs2285803 is a single position in the genome, in or near the PSORS1C2 gene. Published research associates it with multiple myeloma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2285803 linked to?
On MyGeneLog this position is linked to Multiple Myeloma. The research behind each link, and its sources, are set out on that condition page.
Does having rs2285803 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2285803 come from?
GWAS Catalog, Blood cancer journal 2021, PMID:33875642. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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