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Sensitivity to environmental stress and adversity

PTCH1 · rs2282040

What the study found

Who was studied 351,827 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0286 higher; p = 8 × 10−13.

Where it sits Chromosome 9, band 9q22.32 — in an intron of PTCH1.

What each result means

A/A No copy of the version the research linked to Sensitivity to environmental stress and adversity. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Sensitivity to environmental stress and adversity. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Sensitivity to environmental stress and adversity. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2282040

What is rs2282040?

rs2282040 is a single position in the genome, in or near the PTCH1 gene. Published research associates it with sensitivity to environmental stress and adversity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2282040 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2282040 come from?

GWAS Catalog, Acta psychiatrica Scandinavica 2020, PMID:31972866. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sensitivity to environmental stress and adversity (rs2282040). MyGeneLog™. https://www.mygenelog.com/variants/rs2282040

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