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Gut microbiome family abundance (Turicibacteraceae)

PLEKHG1 · rs2279628

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 16,017 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.129 lower (95% confidence interval 0.093-0.166); p = 4 × 10−12.

How common The T allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 6, band 6q25.1 — in an intron of PLEKHG1.

What each result means

C/C No copy of the version the research linked to Gut microbiome family abundance (Turicibacteraceae). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Gut microbiome family abundance (Turicibacteraceae). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Gut microbiome family abundance (Turicibacteraceae). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation
Dekkers KF, Pertiwi K, Baldanzi G, Lundmark P, Hammar U, Moksnes MR, Coward E, Nethander M, Salih GA, Miari M, Nguyen D, Sayols-Baixeras S
and 23 more — show all
Eklund AC, Holm JB, Nielsen HB, Volpiano CG, Méric G, Thangam M, Hakaste L, Tuomi T, Ahlqvist E, Smith CA, Allen M, Reimann F, Gribble FM, Ohlsson C, Hveem K, Melander O, Nilsson PM, Engström G, Smith JG, Michaëlsson K, Ärnlöv J, Orho-Melander M, Fall T
Nature genetics · 2026 · PMID 41688638 · open access

Questions about rs2279628

What is rs2279628?

rs2279628 is a single position in the genome, in or near the PLEKHG1 gene. Published research associates it with gut microbiome family abundance (turicibacteraceae). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2279628 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2279628 come from?

GWAS Catalog, Nature genetics 2026, PMID:41688638. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gut microbiome family abundance (Turicibacteraceae) (rs2279628). MyGeneLog™. https://www.mygenelog.com/variants/rs2279628

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